FP377NOVEL RISK-BASED THRESHOLDS FOR BONE MINERAL BIOMARKERS IN ADVANCED CKD

Ckd-mineral and Bone Disorders (ckd-mbd)

[Brazilian Guidelines for bone and mineral disorders in CKD children].

1.1 Os níveis séricos de cálcio (Ca), fósforo (P), fosfatase alcalina (FA), paratormônio-intacto (PTH), pH e bicarbonato sérico (HCO3) ou reserva alcalina (CO2 total) devem ser determinados em todas as crianças e adolescentes nos estágios II a V da doença renal crônica (DRC). A frequência dessas determinações deve ser baseada na presença e na magnitude das alterações e na velocidade de progress...

Progression of arterial stiffness is associated with changes in bone mineral markers in advanced CKD

BACKGROUND Arterial stiffness is an independent predictor of all-cause and cardiovascular mortality in patients with chronic kidney disease (CKD). There are limited prospective data however on progression of arterial stiffness in CKD, including evaluating associations with bone mineral markers such as fibroblast growth factor 23 (FGF23) and soluble α-klotho (sKl). METHODS In this prospective,...

Bisphophonates in CKD Patients with Low Bone Mineral Density

Patients with chronic kidney disease-mineral and bone disorder (CKD-MBD) have a high risk of bone fracture because of low bone mineral density and poor bone quality. Osteoporosis also features low bone mass, disarranged microarchitecture, and skeletal fragility, and differentiating between osteoporosis and CKD-MBD in low bone mineral density is a challenge and usually achieved by bone biopsy. B...

CKD-mineral and bone disorder management in kidney transplant recipients.

Kidney transplantation, the most effective treatment for the metabolic abnormalities of chronic kidney disease (CKD), only partially corrects CKD-mineral and bone disorders. Posttransplantation bone disease, one of the major complications of kidney transplantation, is characterized by accelerated loss of bone mineral density and increased risk of fractures and osteonecrosis. The pathogenesis of...